cell_type large_stringlengths 4 10 | description large_stringlengths 1.02k 1.5k |
|---|---|
A2058 | A2058 is a BRAF V600E amelanotic cutaneous melanoma line from a lymph node metastasis (43-year-old male). The defining oncogenic context is constitutive RAS-RAF-MEK-ERK activation (BRAF V600E) compounded by reduced PTEN protein, partially derepressing PI3K-AKT signaling; BRAF V600E has been reported in this specific co... |
A549 | A549 is a KRAS G12S non-small-cell lung adenocarcinoma line with alveolar type II features (58-year-old male). KRAS G12S plus STK11 (LKB1) loss drives constitutive RAS-MAPK and PI3K-AKT-mTORC1 with no AMPK-mediated brake; mTORC1 elevates cap-dependent translation and 5'-TOP mRNAs (ribosomal proteins, eEF1A, eEF2, PABPC... |
COLO-320 | COLO 320 is a colorectal adenocarcinoma line with mixed neuroendocrine (APUD) features from the sigmoid colon (55-year-old female). The defining lesion is ~30-fold MYC amplification carried on extrachromosomal DNA in COLO 320DM and on integrated HSRs in COLO 320HSR; ecDNA hubs in DM produce cooperative MYC transcriptio... |
HCT 116 | HCT 116 is a microsatellite-unstable (MSI-H), MMR-deficient colorectal carcinoma line (48-year-old male). Co-occurring KRAS G13D, PIK3CA H1047R, and CTNNB1 S45del activate RAS-MAPK, PI3K-AKT-mTOR, and Wnt simultaneously; Wnt-target genes (MYC, LGR5, AXIN2, CD44) are upregulated through stabilized beta-catenin even thou... |
Hep G2 | Hep G2 is a hepatoblastoma line (originally classified as hepatocellular carcinoma) from a 15-year-old male, with a fetal hepatocyte transcriptional state. CTNNB1 exon 3 deletion produces constitutive Wnt activation, so Wnt-target genes (MYC, AXIN2, LGR5, CD44, GLUL) are upregulated; NRAS Q61L adds RAS-MAPK activation;... |
JURKAT | JURKAT (Clone E6-1) is a T-cell acute lymphoblastic leukemia line from a 14-year-old male, the canonical TCR signaling model. PTEN protein is undetectable in this line (reported as biallelic loss in primary literature) and INPP5D (SHIP) carries two heterozygous loss-of-function alleles; the combined effect elevates PI3... |
K-562 | K-562 is a chronic myelogenous leukemia line in blast crisis from a 53-year-old female, the first established human CML line. The BCR-ABL1 Philadelphia fusion (b3a2 transcript) drives constitutive PI3K-AKT-mTOR, JAK-STAT5, and RAS-MAPK signaling; mTOR hyperphosphorylates 4E-BP1 and frees eIF4E, elevating cap-dependent ... |
MCF7 | MCF7 is a luminal (ER+ HER2-; PR variable across sub-lines) breast adenocarcinoma line from a pleural effusion (69-year-old female), the canonical estrogen-dependent breast cancer model. ER alpha is the dominant transcription factor: estrogen drives upregulation of PGR, TFF1, GREB1, MYC, cyclin D1 (CCND1), and the broa... |
MDA-MB-231 | MDA-MB-231 is a triple-negative claudin-low breast adenocarcinoma line from a pleural effusion (51-year-old female), the standard mesenchymal TNBC model. ER, PR, and HER2 are absent; claudin-3, claudin-4, and E-cadherin (CDH1) are downregulated; the miR-200 family (miR-200a, miR-200b, miR-200c, miR-141, miR-429) is sup... |
MIA PaCa-2 | MIA PaCa-2 is an undifferentiated pancreatic ductal adenocarcinoma (PDAC) line from a 65-year-old male, classified as quasi-mesenchymal (basal-like and squamous) subtype. Homozygous KRAS G12C drives constitutive RAS-MAPK and PI3K-AKT-mTOR (G12C is atypical for PDAC at ~1 to 3% of cases); homozygous TP53 R248W silences ... |
NALM-6 | NALM-6 is a pre-B acute lymphoblastic leukemia (B-ALL) line from a 19-year-old male at relapse, the standard CD19-CAR-T target line. An IGH-DUX4 fusion on the silenced IGH allele places NALM-6 in the DUX4-rearranged B-ALL subtype. Recurring point mutations include heterozygous NRAS A146T and EGFR R1068*. TP53 is wild-t... |
NCI-H23 | NCI-H23 is a KRAS G12C non-small-cell lung adenocarcinoma line from a 51-year-old African American male, an NCI-60 panel member. KRAS G12C drives RAS-MAPK and PI3K-AKT but the line is classified as KRAS-independent and mesenchymal-like, intrinsically resistant to sotorasib but sensitive to adagrasib. Homozygous STK11 (... |
PC-3 | PC-3 is a prostate carcinoma line from a lumbar vertebra bone metastasis (62-year-old male), the standard model for castration-resistant prostate cancer (CRPC). Androgen receptor (AR), prostate-specific antigen (PSA, KLK3), testosterone-5-alpha-reductase, and acid phosphatase are all absent or undetectable; cells do no... |
SW 480 | SW 480 is a Dukes' B colorectal adenocarcinoma line, microsatellite stable and chromosomally unstable (CIN), from the primary tumor of a 51-year-old male donor. APC Q1338* truncates the destruction-complex assembly site and abolishes Axin interaction, producing constitutive nuclear beta-catenin and persistent Wnt-targe... |
BioReason-Cell-Contextual-Data
Context tables for human cell lines and proteins, for the BioReason Cell project.
cells
14 human cell lines.
| column | description |
|---|---|
cell_type |
cell line name |
description |
origin, driver mutations, signaling state and post-transcriptional regulatory context of the cell line |
proteins
101 proteins.
| column | description |
|---|---|
protein |
gene symbol |
protein_name |
UniProt protein name |
uniprot_id |
UniProt accession |
functional_roles |
mRNA stabilizer, mRNA destabilizer, splicing factor, localization factor, or uncharacterized |
protein_function |
function summary focused on mRNA regulation |
mirna_crosstalk_roles |
competitive protectors, cooperative enhancers, miRNA biogenesis, miRNA biogenesis inhibitors, ago associated |
domains |
protein domains |
subcellular_location |
subcellular locations |
interacting_proteins |
interacting proteins from this table |
License
CC BY 4.0
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